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The redox properties of NADs regulate the direction of hundreds of cellular biosynthetic pathways varying from amino acid, lipid and nucleotide synthesis to folate cycle, detoxification reactions of drugs and reactive oxygen species 57
Several GLS inhibitors have been developed, among which CB-839 is currently undergoing clinical trials as a potent, orally bioavailable GLS-selective inhibitor for the treatment of various cancers, including TNBC, NSCLC, and colon cancer (NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600, NCT03057600)
El Pais
doi:10.1016/j.pneurobio.2014.11.004 Evidence-Base Disclosure The published evidence base for Dihexa consists predominantly of preclinical research animal models (often rats or mice) and in vitro cell-culture experiments
Type: Recombinant research-reagent supplier (academic and industry labs) Purity: Research-grade recombinant, batch-to-batch consistency Third-party testing: In-house QC
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